منابع مشابه
The Eukaryotic Ribosome MOLECULAR BIOLOGY
The past decade has seen a remarkable advance in our understanding of ribosomes, the large protein-RNA machines in all cells that use genetic information to synthesize proteins in a process known as translation. Ribosomes from all species consist of two subunits: a small subunit that decodes messenger RNA (mRNA), and a large subunit that catalyzes peptide bond formation between the growing poly...
متن کاملComprehensive molecular structure of the eukaryotic ribosome.
Despite the emergence of a large number of X-ray crystallographic models of the bacterial 70S ribosome over the past decade, an accurate atomic model of the eukaryotic 80S ribosome is still not available. Eukaryotic ribosomes possess more ribosomal proteins and ribosomal RNA than do bacterial ribosomes, which are implicated in extraribosomal functions in the eukaryotic cells. By combining cryo-...
متن کاملTranslational Control by the Eukaryotic Ribosome
The ribosome plays a universally conserved role in catalyzing protein synthesis. Kondrashov et al. (2011) now provide evidence that the loss of function of ribosomal protein L38 in mice leads to a selective reduction in the translation of Hox mRNAs, thus suggesting that ribosomal proteins play a critical role during embryonic development.
متن کاملThe Eukaryotic Ribosome: Current Status and Challenges*
Despite having been identified first, their greater degree of complexity has resulted in our understanding of eukaryotic ribosomes lagging behind that of their bacterial and archaeal counterparts. A much more complicated biogenesis program results in ribosomes that are structurally, biochemically, and functionally more complex. However, recent advances in molecular genetics and structural biolo...
متن کاملA ribosome-anchored chaperone network that facilitates eukaryotic ribosome biogenesis
Molecular chaperones assist cellular protein folding as well as oligomeric complex assembly. In eukaryotic cells, several chaperones termed chaperones linked to protein synthesis (CLIPS) are transcriptionally and physically linked to ribosomes and are implicated in protein biosynthesis. In this study, we show that a CLIPS network comprising two ribosome-anchored J-proteins, Jjj1 and Zuo1, funct...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1985
ISSN: 0014-5793
DOI: 10.1016/0014-5793(85)80454-3